ea0014oc3.6 | Endocrine tumors & neoplasia | ECE2007
Martineti Valentina
, Mascherini Massimiliano
, Mavilia Carmelo
, Sala Silvia Carbonell
, Tognarini Isabella
, Azzari Chiara
, Stefanini Federico Mattia
, Tonelli Francesco
, Brandi Maria Luisa
Epidemiological data clearly evidence a protective role of estrogens against the development of colon cancer and ERβ has been identified as the predominant ER subtype in human colon. More recently it has been identified as a favourable prognostic marker in this disease, possibly explaining the protective effect of estrogens against colon cancer development. To understand the specific role and mechanism of action of ERβ in colon tumorigenesis we developed an in vit...